New LC-MS workflow provides higher quality data for clinical research samples

Attendees at MEDLAB 2017 had the opportunity to see a powerful fully-integrated liquid chromatography- mass spectrometr y (LC -MS) workflow designed to offer accurate and consistent analysis of the most challenging and complex sample matrices for clinical researchers.
This workflow is part of a research collaboration with Amerispec Diagnostics, a Dubai-based reference laborator y focused on offering cutting-edge technologies based on mass spectrometry to the United Arab Emirates (UAE), the Gulf Cooperation Council (GCC) and the Middle East. The LC-MS workflow is designed to provide a comprehensive
solution for clinical research laboratories evaluating how to improve separation, low-limit detection and quantification of molecules in biological matrices such a s s t e ro i d s , v i t ami n D a n d i t s me t a b o l i t e s ,
immunosuppressants, anti-epileptics and amino acids. In addition, the workflow is designed to facilitate drug monitoring research of prescribed and illicit drugs, while addressing the analytical needs of clinical translational researchers working on transitioning new protein biomarkers toward clinical laboratories.
“We understand the need for established processes designed to offer robust, sensitive and reliable research methods that can lead to high-quality, reproducible data,” said Lisa Thomas, senior director, clinical and forensic markets, chromatography and mass spectrometry, Thermo Fisher. “The collaboration with Amerispec will enhance our customers’ capabilities in these regions – ultimately accelerating their research and enabling them to make meaningful clinical discoveries.”
“We aim to provide scientists and academic research institutions in the UAE and the region access to novel t e c h n o l o g i e s , w h i c h w i l l l e a d t o f u r t h e r advancements in clinical research,”said Yasser Ismail, founder and president of Amerispec Diagnostics. “We will be improving patient outcomes by localizing critical assays that are currently sent to the US and Europe – resulting in a drastic reduction in time to result. With adjacency to many prominent global scientific organizations, and the support of the Dubai Creative Cluster Authorities and the Dubai
Science Park, we are able to further support our mission.”
C o m p r i s e d o f h a rd w a re , s o f t w a re , t r a i n i n g application and service support, the new workflow
aims to standardize the future analysis of samples and better leverage the strengths of modern, highthroughput
systems. Utilizing the sensitivity and speed of a system such as the Thermo Scientific Endura mass spectrometer combined with a multichannel UHPLC system incorporating online sample preparation with turboflow technology for cost-effective sample analysis such as the Thermo Scientific Prelude SPLC, together with advanced software, enables clinical research scientists to obtain the quantitative accuracy of LC-MS with confidence.